Hyperbaric Oxygen & Neurological Disease

Hyperbaric Therapy has a wealth of data in Neurology

Background: 

The most important metabolic effects of HBO are on the Central Nervous System. 

The brain has unusually high resting energy requirements, which can only be met by oxidative breakdown of substrate.

Cerebral metabolism is closely tied to blood flow.

The brain, although it makes up only 2% of the body weight, consumes 20% of the oxygen taken in.

Furthermore, the brain cannot store oxygen and therefore cannot tolerate being without oxygen for more than a few minutes.

We added Hyperbaric Oxygen to the offerings of our Edmonton office primarily to supersede these challenges and enhance our ability to treat Neurological Disease.

Hyperbaric Effects in Neurology

• Improvement of microcirculation (via angiogenesis)

• Preservation of damaged tissue (rendered inactive by ischemia/hypoxia). 

• Improvement of cerebral metabolism

• Increasing mitochondrial function

• Stem cell mobilization 

In animal models, HBO increases the expression of Sirt1, Nrf2, and superoxide dismutase for modulating inflammation and promoting longevity.

It is mention worthy that what sets Hyperbaric Oxygen apart from other Naturopathic therapies is that the changes induced by HBO are anatomical changes to the nervous system - that is they are not transient.

These effects are unique to Hyperbaric Oxygen; no other Naturopathic therapies we offer at our Edmonton clinic are able to replicate these effects.

Cognitive Function

A meta-analysis by You 2019 looked at twenty-five randomized clinical trials involving 1,954 patients and looked at Hyperbaric Treatment along with nootropic medications.

The results indicated that additional HBOT strikingly improved the Mini-Mental State Examination and activities of daily living.

The authors concluded "the present meta-analysis suggested that HBOT can be recommended as an effective and safe complementary therapy for the treatment of Vascular Dementia."

Xu 2019 looked at 158 patients with Vascular Dementia which were randomly divided into control group and Hyperbaric groups.

Hyperbaric Oxygen was given 5 days per week, 60 min for each session at 2.0 ATA for 12 weeks.

After treatment, compared with the control group, the MMSE scores were significantly increased. 

The authors concluded "HBO therapy can improve cognitive function in patients with VD, and its mechanism may be related to elevated serum Humanin levels."

In Naturopathic medicine many cognitive enhancers or "nootropics" exist.

Some of our Naturopathic Doctors' favorites include Huperzine from Chinese club moss Huperzia serrata, which acts as a cholinesterase inhibitor which we use in conjunction with Hyperbaric Oxygen at our Edmonton office.

Alzheimer's

Harch 2018 discusses a case report of a 58-year-old female was diagnosed with Alzheimer's dementia which was rapidly progressive in the 8 months prior to treatment.

She received 40 treatments of Hyperbaric Oxygen.

After 21 treatments the patient reported increased energy, activity, mood, and performance of activities of daily living.

After 40 treatments, she reported increased memory, concentration, sleep, conversation, appetite, ability to use the computer, resolved anxiety, and decreased disorientation and frustration. 

PET scans showed up to a 38% increase in brain metabolism, including typical Alzheimer brain areas.

Dr. Dale Bredesen has published some excellent literature on Functional and Naturopathic medicine approaches to Alzheimer's.

Termed "ReCODE" – reversal of cognitive decline – a protocol that has reversed symptoms in patients with mild cognitive impairment and Alzheimer’s disease.

The Naturopathic Doctors at our Edmonton office use Acetyl-L-Carnitine, CoQ10 and NAD+ as well as Ginkgo biloba which are all strongly synergistic with Hyperbaric Oxygen for improving mitochondrial function and blood flow in this population.

Parkinson's 

Neretin (1989) looked at Hyperbaric Therapy for the treatment of 64 patients suffering from Parkinsonism.

Hyperkinesia, bradykinesia, and muscle rigidity, can develop with brain lesions of varied etiology. 

Hyperbaric Oxygen was given daily for 8-12 treatments between 1.3 and 2.0 atm for 40-60 minutes with nootropic medications.

Beneficial effects were seen 55/64 patients (86%).  

Xu 2018 published a case report - a 45-year-old male Parkinson's patient with severe depression and anxiety that refused to be treated with mood modifying therapies.  

Two 40 minute HBOT sessions were used daily at 2.0 ATA for 30 days

Mood, as well as the resting tremor and bradykinesia improved significantly.

Sechi 1996 who reported a 42% decline in Parkinson's disability with frequent IV Glutathione treatment for 30 days. 

Intravenous Glutathione Therapy is a favorite of our Naturopathic Doctors for Parkinson's at our Edmonton clinic in addition to Hyperbaric Oxygen.

 
Hyperbaric Oxygen and Neurological Disease

MS 

Oriani et al (1990) looked at 44 MS patients and compared Hyperbaric Oxygen at 2.5 ATA against compressed air.

90 minute treatments were used for 1 month before initiating maintenance treatments for a 1 year period. 

In the Hyperbaric group, 64% reported benefits versus only 5% in the Hyperbaric air group.

Pallota (1986) studied 22 RRMS patients for 8 years with Hyperbaric treatment.

An initial course of 20 treatments, with half treated (11/22) treated with two HBO treatments every 3 weeks thereafter.

The relapse frequency decreased dramatically in the 11/22 patients over the 8 year period. 

MS is certainly an area our Naturopathic doctors are experienced with at our Edmonton clinic.

Our Naturopaths screen for food sensitivities, assess gut health, chronic infections, toxicities and use IV Glutathione, IV Myers and IV NAD.

It is extremely challenging to improve functional status in patients with Multiple Sclerosis - as such, for patients at our Edmonton office we always discuss the use of Hyperbaric Oxygen, as well as stem cell transplants (done abroad).

For our entire discussion on Hyperbaric Oxygen and MS visit our MS Section. 

Stroke 

A tremendous amount of data exists on potential positive effects of Hyperbaric Therapy for chronic Stroke sequela.

Neubauer and End (1980) used Hyperbaric Therapy for both acute and the chronic Stroke at pressures of 1.5–2 ATA up to 60 minutes twice daily.

The authors reported that 65% of the chronic Stroke patients reported an improvement in their quality of life.

Efrati et al.(2013) studied 74 chronic Stroke patients commencing Hyperbaric Treatment for 60 days.

5 weekly sessions for 90 minutes at 2 ATA for a total of 40 treatments between 6 and 36 months after the initial insult.

The authors found that Hyperbaric Oxygen Therapy led to significant neurological improvements in this chronic Stroke population.

Citicoline is Naturopath favorite at our clinic for both MS and Stroke. 

Alvarez-Sabín 2013 gave citicoline (1 g/day) for 12 months vs. no citicoline in patients selected 6 weeks after suffering a stroke - the citicoline group showed a better functional outcome.

Improving functional outcomes in chronic Stroke is extremely challenging, as such the Naturopathic Doctors at our Edmonton Clinic defer heavily to Hyperbaric Oxygen for this purpose.

For our entire discussion on Hyperbaric Oxygen and Stroke visit our Stroke section. 

TBI

Anti-inflammatory, hyperoxygenation and neovascular Hyperbaric effects make it an attractive option for use in chronic TBI. 

Harch et al. 2012, looked at Hyperbaric Oxygen Therapy in 16 war veterans with Traumatic Brain Injury as well as Post-Concussion Syndrome and PTSD.

Hyperbaric Therapy used was 40 sessions at 1.5 ATA for 60 minutes in 30 days. 

80% of the subjects reported an improvement in the majority of their symptoms.

IV Glutathione with supportive nutrients are some of our Naturopaths' favorites for augmenting TBI symptoms.

We've seen some of our Edmonton TBI patients respond rapidly and dramatically to IV Glutathione.

In our experience with our Edmonton patients, TBI frequently rapidly and favorably responds to the use of Hyperbaric Oxygen. 

For our entire discussion on Hyperbaric Oxygen and TBI visit our TBI Section

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